Final Scientific Programme

Saturday October 1, 2011
18:30-19:00 Opening Ceremony
19:00-20:00 Plenary Lecture
20 years from NCX purification and cloning: milestones, Kenneth D Philipson
Chair: Lucio Annunziato
20:00-21:00 Welcome Cocktail
Sunday October 2, 2011
08:30-10:30 Structural and Functional Aspects of NCX
Session Chair: Kenneth D Philipson and Mark Hilge
08:30-09:00 Crystal structure of calcium regulatory domains of NCX, Lei Zheng
09:00-09:30 Calcium regulation in NCX features: a dual electrostatic switch mechanism, Mark Hilge
09:30-10:00 NCX1: mechanisms of transport and regulation, Michela Ottolia
10:00-10:30 Structure-activity relationship of regulatory CBD domains: how calcium switch decodes regulatory signal ?, Daniel Khananshvili
10:30-11:00 COFFEE BREAK
11:00-13:00 Structural and Functional Aspects of NCKX
Session Chair: Jonathan Lytton and Paul P Schnetkamp
11:00-11:30 Structure-function relationship for NCKX, Paul P Schnetkamp
11:30-12:00 NCKX: key contributors to calcium signaling, Jonathan Lytton
12:00-12:30 Regulation of sodium/calcium exchangers, NCX and NCKX, in reproductive tissues, Eui-Bae Jeung
12:30-13:00 NCKX5 as a regulator of human epidermal melanogenesis and natural skin colour, Rebecca Ginger


Poster Session and Lunch
14:00-15:30 Genetic and Epigenetic Regulation of NCX
Session Chair: Donald Menick and Gianfranco di Renzo
14:00-14:30 The role of acetylation in regulating NCX expression, Donald Menick
14:30-15:00 NCX as a new target of HIF-1, Valeria Valsecchi
15:00-15:30 The transcriptional repressor REST regulates NCX1 expression in neuronal cells, Luigi Formisano

16:30 Island Tour by Boat

Monday October 3, 2011
08:30-10:00 Regulatory Mechanisms on Na+/Ca2+ exchangers
Session Chair: Luis Beaugé and Reinaldo Dipolo
08:30-09:00 Metabolic regulation of NCX: new developments, Luis Beaugé
09:00-09:30 Phospholemman: endogenous regulator of cardiac NCX, JuFang Wang
09:30-10:00 Regulation of NCX activity by creatine kinase, Lung-Sen Kao
10:00-10:30 COFFEE BREAK
10:30-12:30 Subcellular Localization and Function of NCX in Calcium Storing Organelles, Mitochondria and Nucleus
Session Chair: André Herchuelz and Zhigang Xiong
10:30-11:00 NCX3 on the outer mitochondria membrane regulates mitochondrial calcium concentration through AKAP121, Antonella Scorziello
11:00-11:30 NCLX is an essential component of mitochondrial Na+/Ca2+ exchange, Israel Sekler
11:30-12:00 Role of mitochondrial NCX (NCLX) on antigen-receptor mediated Ca2+ signaling in B lymphocytes, Satoshi Matsuoka
12:00-12:30 Expression and function of nuclear NCX in neurons, Agnese Secondo


Poster Session and Lunch
13:30-16:30 NCX in Neurodegenerative Diseases and Diabetes (ECM accredited)
Session Chair: Lucio Annunziato and Mordecai Blaustein
13:30-14:00 Transgenic mice as a strategy to unravel the protective role of NCX in brain ischemia, Lucio Annunziato
14:00-14:30 NCX1 and NCX3 as effectors of ischemic preconditioning and postconditioning, Giuseppe Pignataro
14:30-15:00 The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease, Andrey Abramov
15:00-15:30 COFFEE BREAK
15:30-16:00 Role of NCX in the cerebellum, Ruth M Empson
16:00-16:30 NCX1 in the beta-cell: role in beta-cell protection and regeneration, André Herchuelz
17:30 Visit to Aragonese Castle

Tuesday October 4, 2011
08:30-12:00 Emerging Role of NCX Activity in Immune and Glia Cells (ECM accredited)
Session Chair: Hannah Rahamimoff and Alexej Verkharatsky
08:30-09:00 NCX expression and activity in microglia and oligodentrocytes, Francesca Boscia
09:00-09:30 Bradykinin-induced microglial migration depends on calcium influx through NCX, Mami Noda
09:30-10:00 Role of the reverse NCX under physiological conditions in modulating the L-Glutamate Ca2+i-signaling in cerebellar type I astrocytes, Reinaldo Dipolo
10:00-10:30 COFFEE BREAK
10:30-11:00 Sodium signalling in neuronal-glial communications, Alexej Verkhratsky
11:00-11:30 The involvement of Immunophilins in functional expression of NCX proteins, Hannah Rahamimoff
11:30-12:00 Expression and function of NCX1 and NCX3 in human macrophages and monocytes, Gianni Marone


Poster Session and Lunch
13:00-14:30 NCX in the Heart and Vascular Smooth Muscle
Session Chair: Donald W Hilgemann and David A Eisner
13:00-13:30 NCX: a key player in the regulation of arterial contraction and blood pressure, Jin Zhang
13:30-14:00 The role of NCX in stable and unstable control of systolic calcium in the heart, David A Eisner
14:00-14:30 Colocalization of voltage-gated sodium channels with NCX in cardiomyocytes, Glen Tibbits
14:30-15:00 COFFEE BREAK
15:00-17:00 NCX Role in Hypertension, Heart Failure, Ischemia Reperfusion, and Arrhythmias (ECM accredited)
Session Chair: Bruno Trimarco and Karin Sipido
15:00-15:30 The role of NCX1 in cardiac interval-strength mechanisms using trangenic models, Donald W Hilgemann
15:30-16:00 T-tubules remodeling, RyR cluster organization and NCX, Karin Sipido
16:00-16:30 Role of NCX in heart failure, ischemia/reperfusion, and arrhythmias: Lessons from NCX knock-out mice, Joshua I Goldhaber
16:30-17:00 Cross-talk between plasma membrane Na+/Ca2+ exchanger-1 and TRPC/Orai containing channels: key players in arterial hypertension, Vera Golovina
20:00 at Regina Isabella
Talk on NCX: "Livin with NCX - and lovin it",
Mordecai Blaustein
20:30 Social Dinner

Wednesday October 5, 2011
09:00-11:30 NCX Partners in Ionic Homeostasis: ASIC, NMDA, NHE and TRPC
Session Chair: John F MacDonald and Dandan Sun
09:00-09:30 NHE as regulator of intracellular pH and cell volume, John Orlowski
09:30-10:00 Activation of microglia depends on NHE-mediated H+ homeostasis, Dandan Sun
10:00-10:30 COFFEE BREAK
10:30-11:00 NMDA and TRPM2 channels: new partners in dysregulation of calcium homeostasis, John F MacDonald
11:00-11:30 ASICs as potential targets for neurological disorders, Zhigang Xiong
11:30-13:00 NCX as Therapeutical Target: How to Make a Dream a Reality
Session Chair: Larry Hryshko and Daniel Khananshvili
11:30-12:00 Can selective isoform activators of NCX serve as new tools for neurodegenerative disease? Pasquale Molinaro
12:00-12:30 New perspectives in the development of NCX inhibitors, Larry Hryshko
12:30-13:00 A high-throughput assay for the identification of NCX1 inhibitors as novel therapeutic agents, Michela Stucchi
13:00  Conclusive Remarks

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